Article
Genotypic Analysis of COL4A1 Gene in Diabetic Nephropathy and Type 2 Diabetes Mellitus Patients: A Comparative Genetic Study.
DNA and cell biology - 1 Sept 2023
Shukla Neha, Kumari Shivani, Verma Poornima, Kushwah Atar Singh, Banarjee Monisha, Sankhwar S N, Srivastava Aneesh, Ansari M S, Gautam Naveen Kumar
Abstract excerpt
Diabetic nephropathy (DN) is specified by microalbuminuria, glomerular lesions, and renal fibrosis leading to end-stage renal disease. The pathophysiology of DN is multifactorial as a result of gene-environment interaction. Clinical studies suggested that gene mutations affect various pathways involved in DN, including extracellular matrix (ECM). During chronic hyperglycemia, collagen type-4-mediated ECM...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
