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Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population.

Molecular biology reports - 19 Oct 2024

Jabeen Anjum, Riaz Samreen, Usman Muhammad, Parveen Asia, Mukhtar Maryam, Wajid Abdul, Hanif Atif, Batool Andleeb

Abstract excerpt

BACKGROUND: Type 1 diabetes (T1D) is an organ-specific autoimmune disorder characterized by the destruction of pancreatic β cells, leading to absolute insulin deficiency. The genes NLRP3, ICAM-1, PTPN22, and INS are reportedly associated with T1D in other populations. However, the genetic pattern of T1D in the Pakistani population is not clear. This study aimed to find the association of polymorphisms in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39425874
DOI: 10.1007/s11033-024-09983-8

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