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Article

Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression.

Journal of autoimmunity - 1 Jan 2017

Zerif Echarki, Maalem Aida, Gaudreau Simon, Guindi Chantal, Ramzan Muhammad, Véroneau Steeve, Gris Denis, Stankova Jana, Rola-Pleszczynski Marek, Mourad Walid, Dupuis Gilles, Amrani Abdelaziz

Abstract excerpt

Defects in dendritic cells (DCs) development and function lead to autoimmune disorders. Autoimmune diabetes in humans and NOD mice results from a breakdown of self-tolerance, ending in T cell-mediated β-cell destruction. DCs dysfunction in NOD mice results in part from a defect in the JAK-STAT5 signaling pathway associated with the idd4 susceptibility locus. The involvement of Stat5b in DCs tolerogenic functions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27634616
DOI: 10.1016/j.jaut.2016.09.001

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