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Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity.

Diabetes - 1 Aug 2003

Ma Linlin, Qian Shiguang, Liang Xiaoyan, Wang Lianfu, Woodward Jennifer E, Giannoukakis Nick, Robbins Paul D, Bertera Suzanne, Trucco Massimo, Fung John J, Lu Lina

Abstract excerpt

Abnormalities of dendritic cells (DCs) have been identified in type 1 diabetic patients and in nonobese diabetic (NOD) mice that are associated with augmented nuclear transcription factor (NF)-kappaB activity. An imbalance that favors development of the immunogenic DCs may predispose to the disease, and restoration of the balance by administration of DCs deficient in NF-kappaB activity may prevent diabetes. DCs...

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Identifiers

PMID: 12882913
DOI: 10.2337/diabetes.52.8.1976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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