Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Next-generation sequence analysis of genes associated with obesity and nonalcoholic fatty liver disease-related cirrhosis in extreme obesity.

Human heredity - 1 Jan 2013

Gerhard Glenn S, Chu Xin, Wood G Craig, Gerhard Genevieve M, Benotti Peter, Petrick Anthony T, Gabrielsen Jon, Strodel William E, Still Christopher D, Argyropoulos George

Abstract excerpt

OBJECTIVES: Genome-wide association studies (GWAS) have led to the identification of single nucleotide polymorphisms in or near several loci that are associated with the risk of obesity and nonalcoholic fatty liver disease (NAFLD). We hypothesized that missense variants in GWAS and related candidate genes may underlie cases of extreme obesity and NAFLD-related cirrhosis, an extreme manifestation of NAFLD....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Exome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Liver

Share to Genetic Association Studies

Share to Liver Cirrhosis

Share to Non-alcoholic Fatty Liver Disease

Share to Obesity, Morbid

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 24081230
DOI: 10.1159/000351719
PMCID: PMC3981063

Genes

BBS1
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Next-generation sequence analysis of genes associated with obesity and nonalcoholic fatty liver disease-related cirrhosis in extreme obesity.PMID 24081230Read ↗

Genome-wide analysis of hepatic lipid content in extreme obesity.Semantic proximity Read ↗

Comparing rare variants versus common in the pathogenesis of nonalcoholic fatty liver disease: a whole exome sequencing approach.Semantic proximity Read ↗

Rare ATG7 genetic variants predispose patients to severe fatty liver diseaseSemantic proximity Read ↗

Investigating genetic variants in early-onset obesity through exome sequencing: A retrospective cohort study.Semantic proximity Read ↗

Screening for rare variants in the PNPLA3 gene in obese liver biopsy patients.Semantic proximity Read ↗

Targeted Next-Generation Sequencing of the Leptin-Melanocortin Pathway in Severe Obesity.Semantic proximity Read ↗

A Targeted Next Generation Sequencing Panel for Non-syndromic Early Onset Severe Obesity and Identification of Novel Likely -Pathogenic Variants in the MC4R and LEP Genes.Semantic proximity Read ↗

Genomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort studySemantic proximity Read ↗

Protein-truncating variants in<i>BSN</i>are associated with severe adult-onset obesity, type 2 diabetes and fatty liver diseaseSemantic proximity Read ↗

Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing.Semantic proximity Read ↗

Association of MTTP gene variants with pediatric NAFLD: A candidate-gene-based analysis of single nucleotide variations in obese children.Semantic proximity Read ↗

Germline Mutations in CIDEB and Protection against Liver Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.