Article

Protein-truncating variants in<i>BSN</i>are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease

2023-06-16

Abstract excerpt

Obesity is a major risk factor for many common diseases and has a significant heritable component. While clinical and large-scale population studies have identified several genes harbouring rare alleles with large effects on obesity risk, there are likely many unknown genes with highly penetrant effects remaining. To this end, we performed whole exome-sequence analyses for adult body mass index (BMI) in up to 587,...

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Literature Corpus work: e117723f-ef56-5507-835b-3b5cb37e9e00
DOI: 10.1101/2023.06.14.23291368

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