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Rare ATG7 genetic variants predispose patients to severe fatty liver disease

8 Apr 2022

Abstract excerpt

BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disorders and has a strong heritable component. The aim of this study was to identify new loci that contribute to severe NAFLD by examining rare variants. METHODS: We performed whole-exome sequencing in individuals with NAFLD and advanced fibrosis or hepatocellular carcinoma (n = 301) and examined the enrichment of likely...

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PMID: 35405176
DOI: 10.1016/j.jhep.2022.03.031

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