Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparing rare variants versus common in the pathogenesis of nonalcoholic fatty liver disease: a whole exome sequencing approach.

Journal of gastroenterology and hepatology - 1 Mar 2024

Bale Govardhan, Kulkarni Anand V, Padaki Nagaraja Rao, Menon P Balachandran, Sharma Mithun, Iyengar Sowmya, Sekaran Anuradha, Pawar Smita C, Duvvur Nageshwar Reddy, Vishnubhotla Ravikanth

Abstract excerpt

BACKGROUND/PURPOSE: Genome-wide association studies have reported the association of common variants with nonalcoholic fatty liver disease in genes, namely, PNPLA3/TM6SF2/MBOAT7/HSD17B13, across ethnicities. However, the approach does not identify rarer variants with a higher effect size. We therefore sequenced the complete exonic regions of patients with nonalcoholic steatohepatitis and controls to compare rare...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exome Sequencing
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Non-alcoholic Fatty Liver Disease

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 37939728
DOI: 10.1111/jgh.16394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparing rare variants versus common in the pathogenesis of nonalcoholic fatty liver disease: a whole exome sequencing approach.PMID 37939728Read ↗

Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy.Semantic proximity Read ↗

Genetic Variations and Nonalcoholic Fatty Liver Disease: Field Synopsis, Systematic Meta-Analysis, and Epidemiological Evidence.Semantic proximity Read ↗

Advances in the genetics of nonalcoholic fatty liver disease.Semantic proximity Read ↗

Genetic and metabolic aspects of non-alcoholic fatty liver disease (NAFLD) pathogenicitySemantic proximity Read ↗

Update on NAFLD genetics: From new variants to the clinic.Semantic proximity Read ↗

Genetic Contribution to Non-alcoholic Fatty Liver Disease and Prognostic Implications.Semantic proximity Read ↗

Somatically mutated genes in fatty liver disease have minimal influence on germline riskSemantic proximity Read ↗

A minority of somatically mutated genes in pre-existing fatty liver disease have prognostic importance in the development of NAFLD.Semantic proximity Read ↗

Update on Non-Alcoholic Fatty Liver Disease-Associated Single Nucleotide Polymorphisms and Their Involvement in Liver Steatosis, Inflammation, and Fibrosis: A Narrative ReviewSemantic proximity Read ↗

Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and TherapeuticsSemantic proximity Read ↗

Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD.Semantic proximity Read ↗

Genome-Wide Association Study of Non-Alcoholic Fatty Liver Disease Identifies Association with Apolipoprotein ESemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.