Article
Associations between single-nucleotide polymorphisms in the PI3K-PTEN-AKT-mTOR pathway and increased risk of brain metastasis in patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2013
Li Qianxia, Yang Ju, Yu Qianqian, Wu Huanlei, Liu Bo, Xiong Huihua, Hu Guangyuan, Zhao Jing, Yuan Xianglin, Liao Zhongxing
Abstract excerpt
PURPOSE: Non-small cell lung cancer (NSCLC) metastasizes fairly often to the brain, but identifying which patients will develop brain metastases is problematic. The phosphoinositide 3-kinase (PI3K)-AKT-mTOR signaling pathway is important in the control of cell growth, tumorigenesis, and cell invasion. We hypothesized that genotype variants in this pathway could predict brain metastasis in patients with NSCLC....
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