Article
Associations between single-nucleotide polymorphisms in the PI3K-PTEN-AKT-mTOR pathway and increased risk of brain metastasis in patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2013
Li Qianxia, Yang Ju, Yu Qianqian, Wu Huanlei, Liu Bo, Xiong Huihua, Hu Guangyuan, Zhao Jing, Yuan Xianglin, Liao Zhongxing
Abstract excerpt
PURPOSE: Non-small cell lung cancer (NSCLC) metastasizes fairly often to the brain, but identifying which patients will develop brain metastases is problematic. The phosphoinositide 3-kinase (PI3K)-AKT-mTOR signaling pathway is important in the control of cell growth, tumorigenesis, and cell inva...
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