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Article

The Thr300Ala variant of ATG16L1 is associated with decreased risk of brain metastasis in patients with non-small cell lung cancer.

Autophagy - 3 Jun 2017

Li Qian-Xia, Zhou Xiao, Huang Ting-Ting, Tang Yang, Liu Bo, Peng Ping, Sun Li, Wang Yi-Hua, Yuan Xiang-Lin

Abstract excerpt

Non-small cell lung cancer (NSCLC) often metastasizes to the brain, but identifying which patients will develop brain metastases (BM) is difficult. Macroautophagy/autophagy is critical for cancer initiation and progression. We hypothesized that genetic variants of autophagy-related genes may affect brain metastases (BM) in NSCLC patients. We genotyped 16 single nucleotide polymorphisms (SNPs) in 7...

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Source

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Identifiers

PMID: 28441070
DOI: 10.1080/15548627.2017.1308997
PMCID: PMC5486363

Genes

ATG10
ATG12
ATG3
ATG5
ATG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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