Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma.

doi:10.1016/j.lungcan.2014.08.013

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Article

Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2014

Zhao Ni, Wilkerson Matthew D, Shah Usman, Yin Xiaoying, Wang Anyou, Hayward Michele C, Roberts Patrick, Lee Carrie B, Parsons Alden M, Thorne Leigh B, Haithcock Benjamin E, Grilley-Olson Juneko E, Stinchcombe Thomas E, Funkhouser William K, Wong Kwok-Kin, Sharpless Norman E, Hayes D Neil

Abstract excerpt

BACKGROUND: Brain metastases are one of the most malignant complications of lung cancer and constitute a significant cause of cancer related morbidity and mortality worldwide. Recent years of investigation suggested a role of LKB1 in NSCLC development and progression, in synergy with KRAS alteration. In this study, we systematically analyzed how LKB1 and KRAS alteration, measured by mutation, gene expression (GE)...

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Identifiers

PMID: 25224251
DOI: 10.1016/j.lungcan.2014.08.013
PMCID: PMC4362696

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KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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