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Article

SNPs in the TGF-β signaling pathway are associated with increased risk of brain metastasis in patients with non-small-cell lung cancer.

PloS one - 1 Jan 2012

Li Qianxia, Wu Huanlei, Chen Bei, Hu Guangyuan, Huang Liu, Qin Kai, Chen Yu, Yuan Xianglin, Liao Zhongxing

Abstract excerpt

PURPOSE: Brain metastasis (BM) from non-small cell lung cancer (NSCLC) is relatively common, but identifying which patients will develop brain metastasis has been problematic. We hypothesized that genotype variants in the TGF-β signaling pathway could be a predictive biomarker of brain metastasis...

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Identifiers

PMID: 23284751
DOI: 10.1371/journal.pone.0051713
PMCID: PMC3524120

Genes

INHBC
SMAD6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23284751-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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