Article
Genetic variations in the PI3K-PTEN-AKT-mTOR pathway are associated with distant metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy.
Scientific reports - 23 Nov 2016
Guo Qiaojuan, Lu Tianzhu, Chen Yan, Su Ying, Zheng Yuhong, Chen Zeng, Chen Chao, Lin Shaojun, Pan Jianji, Yuan Xianglin
Abstract excerpt
Distant metastasis is the primary failure pattern of nasopharyngeal carcinoma(NPC) in intensity-modulated radiation therapy(IMRT) era. This study was conducted to find the impact of genetic variations in the phosphatidylinositol 3-kinase(PI3K)/phosphatase and tensin homologue(PTEN)/v-akt murine thymoma viral oncogene homologue(AKT)/mammalian target of rapamycin(mTOR) pathway on the risk of distant metastasis in...
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