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Article

Identification of single nucleotide polymorphisms of the PI3K-AKT-mTOR pathway as a risk factor of central nervous system metastasis in metastatic breast cancer.

European journal of cancer (Oxford, England : 1990) - 1 Dec 2017

Le Rhun Emilie, Bertrand Nicolas, Dumont Aurélie, Tresch Emmanuelle, Le Deley Marie-Cécile, Mailliez Audrey, Preusser Matthias, Weller Michael, Revillion Françoise, Bonneterre Jacques

Abstract excerpt

INTRODUCTION: The PI3K-AKT-mTOR pathway may be involved in the development of central nervous system (CNS) metastasis from breast cancer. Accordingly, herein we explored whether single nucleotide polymorphisms (SNPs) of this pathway are associated with altered risk of CNS metastasis formation in metastatic breast cancer patients. METHODS: The GENEOM study (NCT00959556) included blood sample collection from breast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29103666
DOI: 10.1016/j.ejca.2017.10.006

Genes

AKT1
AKT2
PDK1
FGFR1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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