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Article

Enhancement of protein translocation across the membrane by specific mutations in the hydrophobic region of the signal peptide.

Journal of bacteriology - 1 Mar 1990

Goldstein J, Lehnhardt S, Inouye M

Abstract excerpt

The hydrophobic region of the signal peptide of the OmpA protein of the Escherichia coli outer membrane was extensively altered in its hydrophobicity and predicted secondary structure by site-specific mutagenesis. The mutated signal peptides were fused to nuclease A from Staphylococcus aureus, and the function of the signal peptide was examined by measuring the rate of processing of the signal peptide. Six of the...

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Identifiers

PMID: 2407717
DOI: 10.1128/jb.172.3.1225-1231.1990
PMCID: PMC208587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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