Article
A comparative analysis of single- and multiple-residue substitutions in the alkaline phosphatase signal peptide.
Biopolymers - 1 Jan 1990
Kendall D A, Doud S K, Kaiser E T
Abstract excerpt
The alkaline phosphatase signal peptide participates in transport of the enzyme to the periplasmic space of Escherichia coli. The signal sequence, like that of other signal peptides, is composed of a polar amino-terminal segment, a central region rich in hydrophobic residues and a carboxy-terminal region recognized by signal peptidase. We have previously shown that an alkaline phosphatase signal peptide mutant...
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