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Article

In vivo effect of asparagine in the hydrophobic region of the signal sequence.

The Journal of biological chemistry - 5 Aug 1991

Goldstein J, Lehnhardt S, Inouye M

Abstract excerpt

On the basis of the biophysical studies on the synthetic mutant (Ile-8----Asn) OmpA signal peptide in the preceding paper (Hoyt, D. C., and Gierasch, L.M. (1991) J. Biol. Chem. 266, 14406-14412), the in vivo effects of the same mutation were examined by fusing the mutant OmpA signal sequence to Staphylococcus aureus nuclease or TEM beta-lactamase. The mutation in which the isoleucine residue at position 8 of the...

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PMID: 1860848

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