Article
The amino-terminal charge and core region hydrophobicity interdependently contribute to the function of signal sequences.
The Journal of biological chemistry - 30 Aug 1996
Izard J W, Rusch S L, Kendall D A
Abstract excerpt
We have constructed a series of signal sequence mutants that contain negatively charged amino termini and simplified core regions of varying hydrophobicity levels. This series provides a means of exploring the relative roles of the amino terminus and the hydrophobic core region during transport....
Topics
- Amino Acid Sequence
- Biological Transport
- DNA, Recombinant
- Molecular Sequence Data
- Mutation
- Protein Sorting Signals