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Article

The amino-terminal charge and core region hydrophobicity interdependently contribute to the function of signal sequences.

The Journal of biological chemistry - 30 Aug 1996

Izard J W, Rusch S L, Kendall D A

Abstract excerpt

We have constructed a series of signal sequence mutants that contain negatively charged amino termini and simplified core regions of varying hydrophobicity levels. This series provides a means of exploring the relative roles of the amino terminus and the hydrophobic core region during transport. The signal peptides with highly hydrophobic core regions support a rapid rate of transport in the presence of a...

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PMID: 8702945
DOI: 10.1074/jbc.271.35.21579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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