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Cell Organisation in the Colonic Crypt: A Theoretical Comparison of the Pedigree and Niche Concepts

12 Sept 2013

Abstract excerpt

The intestinal mucosa is a monolayer of rapidly self-renewing epithelial cells which is not only responsible for absorption of water and nutrients into the bloodstream but also acts as a protective barrier against harmful microbes entering the body. New functional epithelial cells are produced from stem cells, and their proliferating progeny. These stem cells are found within millions of crypts (tubular pits)...

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PMID: 24069177
DOI: 10.1371/journal.pone.0073204

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