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Article

The functional proteome landscape of Escherichia coli.

Nature - 1 Dec 2020

Mateus André, Hevler Johannes, Bobonis Jacob, Kurzawa Nils, Shah Malay, Mitosch Karin, Goemans Camille V, Helm Dominic, Stein Frank, Typas Athanasios, Savitski Mikhail M

Abstract excerpt

Recent developments in high-throughput reverse genetics1,2 have revolutionized our ability to map gene function and interactions3-6. The power of these approaches depends on their ability to identify functionally associated genes, which elicit similar phenotypic changes across several perturbations (chemical, environmental or genetic) when knocked out7-9. However, owing to the large number of perturbations, these...

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Identifiers

PMID: 33299184
DOI: 10.1038/s41586-020-3002-5
PMCID: PMC7612278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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