Article
Protein damage, radiation sensitivity and aging.
DNA repair - 1 Aug 2016
Radman Miroslav
Abstract excerpt
This paper promotes a concept that protein damage determines radiation resistance and underlies aging and age-related diseases. The first bottleneck in cell recovery from radiation damage is functional (proteome) rather than informational (DNA), since prokaryotic and eukaryotic cell death correlates with incurred protein, but not DNA, damage. Proteome protection against oxidative damage determines survival after...
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