Aging genomes: a necessary evil in the logic of life.

Abstract excerpt

Genomes are inherently unstable because of the need for DNA sequence variation as a substrate for evolution through natural selection. However, most multicellular organisms have postmitotic tissues, with limited opportunity for selective removal of cells harboring persistent damage and deleterious mutations, which can therefore contribute to functional decline, disease, and death. Key in this process is the role...

Topics

• Aging
• Animals
• DNA Damage
• Genome
• Humans
• Life
• Mutation