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Protein damage, ageing and age-related diseases

1 Mar 2019

Abstract excerpt

Ageing is considered as a snowballing phenotype of the accumulation of damaged dysfunctional or toxic proteins and silent mutations (polymorphisms) that sensitize relevant proteins to oxidative damage as inborn predispositions to age-related diseases. Ageing is not a disease, but it causes (or shares common cause with) age-related diseases as suggested by similar slopes of age-related increase in the incidence of...

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PMID: 30914006
DOI: 10.1098/rsob.180249

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