Article
Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis.
PLoS genetics - 1 Jan 2013
Beaudoin Mélissa, Goyette Philippe, Boucher Gabrielle, Lo Ken Sin, Rivas Manuel A, Stevens Christine, Alikashani Azadeh, Ladouceur Martin, Ellinghaus David, Törkvist Leif, Goel Gautam, Lagacé Caroline, Annese Vito, Bitton Alain, Begun Jakob, Brant Steve R, Bresso Francesca, Cho Judy H, Duerr Richard H, Halfvarson Jonas, McGovern Dermot P B, Radford-Smith Graham, Schreiber Stefan, Schumm Philip L, Sharma Yashoda, Silverberg Mark S, Weersma Rinse K, D'Amato Mauro, Vermeire Severine, Franke Andre, Lettre Guillaume, Xavier Ramnik J, Daly Mark J, Rioux John D
Abstract excerpt
Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet genome-wide significance for these two inflammatory bowel diseases (IBD). These discoveries have already had a tremendous impact on our understanding of the genetic architecture of these diseases and have directed functional studies that...
Topics
- CARD Signaling Adaptor Proteins
- Canada
- Colitis, Ulcerative
- Crohn Disease
- Ethnicity
- Genetic Predisposition to Disease
- Genome-Wide Association Study