Article
Glutathione transferase-A2 S112T polymorphism predicts survival, transplant-related mortality, busulfan and bilirubin blood levels after allogeneic stem cell transplantation.
Haematologica - 1 Jan 2014
Bonifazi Francesca, Storci Gianluca, Bandini Giuseppe, Marasco Elena, Dan Elisa, Zani Elena, Albani Fiorenzo, Bertoni Sara, Bontadini Andrea, De Carolis Sabrina, Sapienza Maria Rosaria, Rizzi Simonetta, Motta Maria Rosa, Ferioli Martina, Garagnani Paolo, Cavo Michele, Mantovani Vilma, Bonafè Massimiliano
Abstract excerpt
Busulfan liver metabolism depends on glutathione, a crucial mediator of cellular and systemic stress. Here we investigated 40 polymorphisms at 27 loci involved in hepatic glutathione homeostasis, with the aim of testing their impact on the clinical outcome of 185 busulfan-conditioned allogeneic transplants. GSTA2 S112T serine allele homozygosity is an independent prognostic factor for poorer survival (RR=2.388),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.