Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.

Chemico-biological interactions - 30 Jul 2010

Zhang Wei, Modén Olof, Mannervik Bengt

Abstract excerpt

Azathioprine has been clinically used for decades in connection with organ transplantation, autoimmune disease, and treatment of cancer. Toxic side-reactions are common and have been linked to the liberation of excessively high concentrations of 6-mercaptopurine and corresponding toxic metabolites. An allelic variant of thiopurine methyltransferase with low activity is associated with elevated concentrations of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Azathioprine
Share to Enzyme Stability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Immunosuppressive Agents

Share to In Vitro Techniques

Share to Mercaptopurine

Share to Thermodynamics

Source

Identifiers

PMID: 20434437
DOI: 10.1016/j.cbi.2010.04.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.PMID 20434437Read ↗

Glutathione transferases in the bioactivation of azathioprine.Semantic proximity Read ↗

Clinical pharmacogenomics of thiopurine S-methyltransferase.Semantic proximity Read ↗

Response to azathioprine treatment in autoimmune hepatitis is dependent on glutathione transferase genotypes.Semantic proximity Read ↗

Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods.Semantic proximity Read ↗

Frequency of thiopurine S-methyltransferase (TPMT) alleles in southeast Iranian population.Semantic proximity Read ↗

Thiopurine S-Methyltransferase Polymorphisms Predict Hepatotoxicity in Azathioprine-Treated Patients with Autoimmune DiseasesSemantic proximity Read ↗

Nomenclature for alleles of the thiopurine methyltransferase gene.Semantic proximity Read ↗

Pharmacogenetics of azathioprine in inflammatory bowel disease: A role for glutathione-S-transferase?Semantic proximity Read ↗

Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine.Semantic proximity Read ↗

Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.Semantic proximity Read ↗

Thiopurine Biotransformation and Pharmacological Effects: Contribution of Oxidative Stress.Semantic proximity Read ↗

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.