Article
The effect of functional MAPKAPK2 copy number variation CNV-30450 on elevating nasopharyngeal carcinoma risk is modulated by EBV infection.
Carcinogenesis - 1 Jan 2014
Yang Lei, Liu Bin, Qiu Fuman, Huang Binfang, Li Yinyan, Huang Dongsheng, Yang Rongrong, Yang Xiaorong, Deng Jieqiong, Jiang Qingping, Zhou Yifeng, Lu Jiachun
Abstract excerpt
UNLABELLED: Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) is recognized as oncogenic and simulative role on tumorigenesis by virtue of abnormal expression in cancer including nasopharyngeal carcinoma (NPC). We hypothesized that the copy number variation (CNV)-30450, which duplicates the MAPKAPK2 promoter, may affect MAPKAPK2 expression and be associated with NPC risk. In two independent...
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