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Article

Genetic polymorphisms of MDM2 and TP53 genes are associated with risk of nasopharyngeal carcinoma in a Chinese population.

BMC cancer - 18 Apr 2010

Xiao Mang, Zhang Lei, Zhu Xinhua, Huang Jun, Jiang Huifen, Hu Sunhong, Liu Yuehui

Abstract excerpt

BACKGROUND: The tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis. Previous case-control studies also revealed TP53 72Arg>Pro and MDM2 309T>G polymorphisms contribute to the risk of common cancers. However, the relationship between these two functional polymorphisms and nasopharyngeal carcinoma (NPC) susceptibility has not been explored. METHODS: In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Restriction Fragment Length

Share to Proto-Oncogene Proteins c-mdm2

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Source

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Identifiers

PMID: 20398418
DOI: 10.1186/1471-2407-10-147
PMCID: PMC2861659

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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