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The protective role of polymorphism <i>MKK4‐</i>1304 T>G in nasopharyngeal carcinoma is modulated by Epstein–Barr virus' infection status

23 Jun 2011

Abstract excerpt

MKK4 is a candidate tumor suppressor, which acts as a critical mediator of Epstein-Barr Virus (EBV)-induced c-Jun N-terminal kinase (JNK) activation. Functional polymorphism MKK4 -1304T>G has been showed to be protective in colorectal cancer or lung cancer. We hypothesized that genetic variants in the MKK4 promoter were associated with the risk of nasopharyngeal carcinoma (NPC). Two common polymorphisms in MKK4,...

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PMID: 21702039
DOI: 10.1002/ijc.26253

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