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Article

Compound classification using image-based cellular phenotypes.

Methods in enzymology - 1 Jan 2006

Adams Cynthia L, Kutsyy Vadim, Coleman Daniel A, Cong Ge, Crompton Anne Moon, Elias Kathleen A, Oestreicher Donald R, Trautman Jay K, Vaisberg Eugeni

Abstract excerpt

Compounds with similar target specificities and modes of inhibition cause similar cellular phenotypes. Based on this observation, we hypothesized that we could quantitatively classify compounds with diverse mechanisms of action using cellular phenotypes and identify compounds with unintended cellular activities within a chemical series. We have developed Cytometrix technologies, a highly automated image-based...

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Source

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PMID: 17110206
DOI: 10.1016/S0076-6879(06)14024-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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