Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2009

Nakamura Tomoki, Gulick James, Colbert Melissa C, Robbins Jeffrey

Abstract excerpt

Mutations within the protein tyrosine phosphatase, SHP2, which is encoded by PTPN11, cause a significant proportion of Noonan syndrome (NS) cases, typically presenting with both cardiac disease and craniofacial abnormalities. Neural crest cells (NCCs) participate in both heart and skull formation, but the role of SHP2 signaling in NCC has not yet been determined. To gain insight into the role of SHP2 in NCC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Craniofacial Abnormalities
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Heart Defects, Congenital

Share to Neural Crest

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Source

Open in PubMed Open full text

Identifiers

PMID: 19541608
DOI: 10.1073/pnas.0902230106
PMCID: PMC2708773

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development.PMID 19541608Read ↗

The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.Semantic proximity Read ↗

Distinct and overlapping functions of ptpn11 genes in Zebrafish development.Semantic proximity Read ↗

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.Semantic proximity Read ↗

SHP2 sails from physiology to pathology.Semantic proximity Read ↗

Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects.Semantic proximity Read ↗

The Cardiac Neural Crest Cells in Heart Development and Congenital Heart DefectsSemantic proximity Read ↗

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.Semantic proximity Read ↗

Dual role for neural crest cells during outflow tract septation in the neural crest-deficient mutant Splotch(2H).Semantic proximity Read ↗

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish.Semantic proximity Read ↗

The role of the protein tyrosine phosphatase SHP2 in ossification.Semantic proximity Read ↗

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.Semantic proximity Read ↗

Noonan syndrome and related disorders: genetics and pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.