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Article

Mutations in c-Ki-ras oncogenes in diseased livers of winter flounder from Boston Harbor.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990

McMahon G, Huber L J, Moore M J, Stegeman J J, Wogan G N

Abstract excerpt

Livers of a natural population of winter flounder from a contaminated site in Boston Harbor were examined for the presence of oncogenes by transfection of DNA into NIH 3T3 mouse fibroblasts. Tissues analyzed contained histopathologic lesions including abnormal vacuolation, biliary proliferation, and, in many cases, hepatocellular and cholangiocellular carcinomas. Fibroblasts transfected with liver DNA samples...

Topics

Animals
Boston
Codon
DNA
Fish Diseases
Flounder
Genes, ras
Liver
Liver Neoplasms
Mice
Mice, Nude
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Seawater

Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 2405390
DOI: 10.1073/pnas.87.2.841
PMCID: PMC53362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2405390-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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