Replication enhancer-independent mutation increases the co-operativity with which an initiator protein binds its origin.

doi:10.1016/0022-2836(90)90013-C

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Article

Replication enhancer-independent mutation increases the co-operativity with which an initiator protein binds its origin.

Journal of molecular biology - 5 Jan 1990

Greenstein D, Horiuchi K

Abstract excerpt

The plus-strand replication origin of bacteriophage fl has a bipartite structure consisting of a required core origin region and an adjacent A + T-rich enhancer sequence that potentiates replication approximately 100-fold. The core origin binds the initiator protein (gpII) and the enhancer binds...

Topics

Base Sequence
Cloning, Molecular
Coliphages
DNA Replication
DNA, Viral
DNA-Binding Proteins
Enhancer Elements, Genetic
Escherichia coli
Genes, Viral
Kinetics
Molecular Sequence Data
Mutation
Viral Proteins

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