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Article

A dual binding site for integration host factor and the response regulator CtrA inside the Caulobacter crescentus replication origin.

Journal of bacteriology - 1 Sept 2003

Siam Rania, Brassinga Ann Karen C, Marczynski Gregory T

Abstract excerpt

The response regulator CtrA controls chromosome replication by binding to five sites, a, b, c, d, and e, inside the Caulobacter crescentus replication origin (Cori). In this study, we demonstrate that integration host factor (IHF) binds Cori over the central CtrA binding site c. Surprisingly, IHF and CtrA share DNA recognition sequences. Rather than promoting cooperative binding, IHF binding hinders CtrA binding...

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Identifiers

PMID: 12949109
DOI: 10.1128/JB.185.18.5563-5572.2003
PMCID: PMC193745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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