Article
Crystal structure of a prokaryotic replication initiator protein bound to DNA at 2.6 A resolution.
The EMBO journal - 1 Sept 1999
Komori H, Matsunaga F, Higuchi Y, Ishiai M, Wada C, Miki K
Abstract excerpt
The initiator protein (RepE) of F factor, a plasmid involved in sexual conjugation in Escherichia coli, has dual functions during the initiation of DNA replication which are determined by whether it exists as a dimer or as a monomer. A RepE monomer functions as a replication initiator, but a RepE dimer functions as an autogenous repressor. We have solved the crystal structure of the RepE monomer bound to an...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Crystallography, X-Ray
- DNA
- DNA-Binding Proteins
- Dimerization
- Escherichia coli
- Escherichia coli Proteins
- Models, Biological
- Models, Molecular