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Article

Crystal structure of a prokaryotic replication initiator protein bound to DNA at 2.6 A resolution.

The EMBO journal - 1 Sept 1999

Komori H, Matsunaga F, Higuchi Y, Ishiai M, Wada C, Miki K

Abstract excerpt

The initiator protein (RepE) of F factor, a plasmid involved in sexual conjugation in Escherichia coli, has dual functions during the initiation of DNA replication which are determined by whether it exists as a dimer or as a monomer. A RepE monomer functions as a replication initiator, but a RepE dimer functions as an autogenous repressor. We have solved the crystal structure of the RepE monomer bound to an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10469640
DOI: 10.1093/emboj/18.17.4597
PMCID: PMC1171534

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Source receipt: pubmed, retrieved 7 Sept 2026.

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