Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CVID-associated TACI mutations affect autoreactive B cell selection and activation.

The Journal of clinical investigation - 1 Oct 2013

Romberg Neil, Chamberlain Nicolas, Saadoun David, Gentile Maurizio, Kinnunen Tuure, Ng Yen Shing, Virdee Manmeet, Menard Laurence, Cantaert Tineke, Morbach Henner, Rachid Rima, Martinez-Pomar Natalia, Matamoros Nuria, Geha Raif, Grimbacher Bodo, Cerutti Andrea, Cunningham-Rundles Charlotte, Meffre Eric

Abstract excerpt

Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity. Heterozygous mutations in the gene encoding the tumor necrosis factor receptor superfamily member TACI are associated with CVID and autoimmune manifestations, whereas two mutated alleles prevent autoimmunity. To assess how the number of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Toll-Like Receptor 9
Share to Antibodies, Antinuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to B-Cell Activating Factor

Share to Common Variable Immunodeficiency

Share to Proto-Oncogene Proteins c-bcl-6

Share to T-Lymphocytes, Helper-Inducer

Share to Toll-Like Receptor 7

Share to Transmembrane Activator and CAML Interactor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 24051380
DOI: 10.1172/JCI69854
PMCID: PMC3786721

Genes

TLR7
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CVID-associated TACI mutations affect autoreactive B cell selection and activation.PMID 24051380Read ↗

TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes.Semantic proximity Read ↗

TACI is mutant in common variable immunodeficiency and IgA deficiency.Semantic proximity Read ↗

Defective peripheral B cell selection in common variable immune deficiency patients with autoimmune manifestationsSemantic proximity Read ↗

Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI.Semantic proximity Read ↗

Transmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency.Semantic proximity Read ↗

Transmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immunodeficiency: clinical and immunologic outcomes in heterozygotes.Semantic proximity Read ↗

Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiencySemantic proximity Read ↗

The impact of TACI mutations: from hypogammaglobulinemia in infancy to autoimmunity in adulthood.Semantic proximity Read ↗

Naturally occurring mutation affecting the MyD88-binding site of TNFRSF13B impairs triggering of class switch recombination.Semantic proximity Read ↗

Autoimmune manifestations in common variable immunodeficiency.Semantic proximity Read ↗

Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency.Semantic proximity Read ↗

Loss of B cell tolerance at the T2/T3a B cell transition is a convergent pathogenic mechanism in common variable immunodeficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.