Article
Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI.
Frontiers in immunology - 1 Jan 2022
Ramirez Neftali, Posadas-Cantera Sara, Langer Niko, de Oteyza Andres Caballero Garcia, Proietti Michele, Keller Baerbel, Zhao Fangwen, Gernedl Victoria, Pecoraro Matteo, Eibel Hermann, Warnatz Klaus, Ballestar Esteban, Geiger Roger, Bossen Claudia, Grimbacher Bodo
Abstract excerpt
Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary immunodeficiency in humans. The genetic cause of CVID is still unknown in about 70% of cases. Ten percent of CVID patients carry heterozygous mutations in the tumor necrosis factor receptor superfamily member 13B gene (TNFRSF13B), encoding TACI. Mutations in TNFRSF13B alone may not be sufficient for the development of CVID,...
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