Autoimmune manifestations in common variable immunodeficiency.

Abstract excerpt

INTRODUCTION: About 20% of subjects with common variable immune deficiency (CVID) develop an autoimmune complication, most often immune thrombocytopenia or hemolytic anemia. While the pathogenesis of autoreactivity is unknown for CVID subjects in general, and to a greater extent in those with autoimmunity, there is a loss of switched memory B cells. DISCUSSION: About 7-8% of CVID subjects have mutations in the...

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