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Article

Transmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency.

Current opinion in allergy and clinical immunology - 1 Dec 2008

Lee John J, Ozcan Esra, Rauter Ingrid, Geha Raif S

Abstract excerpt

PURPOSE OF REVIEW: TNFRSF13B, the gene which encodes transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), is mutated in nearly 10% of patients with common variable immune deficiency (CVID), an antibody deficiency syndrome characterized by loss of memory B cells and plasma cells. This review discusses the normal function of TACI and the role of TACI mutants in CVID. RECENT...

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Identifiers

PMID: 18978466
DOI: 10.1097/ACI.0b013e3283141200

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