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Article

Coexistent alterations of BAFF and B-cell phenotypes in complicated CVID course.

The Journal of allergy and clinical immunology - 1 Sept 2026

Matson Erik M, Ware Matthew S, Feng Feng, Yu Lingge, Beane Jennifer E, Belkina Anna C, Maglione Paul J

Abstract excerpt

BACKGROUND: Common variable immunodeficiency (CVID) is a primary immunodeficiency marked by impaired antibody production and infection susceptibility, with about half the patients developing noninfectious complications. B-cell activating factor (BAFF) elevation and genetic variants in a BAFF receptor (BAFF-R), transmembrane activator and CAML interactor (TACI), frequently occur in CVID. Although these findings...

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Topics

Humans
B-Cell Activating Factor
Common Variable Immunodeficiency
B-Cell Activation Factor Receptor
Transmembrane Activator and CAML Interactor Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

B-Lymphocytes

B-Lymphocyte Subsets

Female

Phenotype

Male

Adult

Lymphocyte Activation

Cytopenia

Source

Open in PubMed Open full text

Identifiers

PMID: 42219089
DOI: 10.1016/j.jaci.2026.04.029
PMCID: PMC13367221

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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