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Article

TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes.

The Journal of allergy and clinical immunology - 1 Feb 2013

Martinez-Gallo Monica, Radigan Lin, Almejún María Belén, Martínez-Pomar Natalia, Matamoros Núria, Cunningham-Rundles Charlotte

Abstract excerpt

BACKGROUND: Mutations in the gene coding for the transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) are found in 8% to 10% of subjects with common variable immunodeficiency (CVID). Although heterozygous mutations may coincide with immunodeficiency in a few families, most mutation-bearing relatives are not hypogammaglobulinemic. Thus, the role of TACI mutations in producing the...

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Source

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Identifiers

PMID: 23237420
DOI: 10.1016/j.jaci.2012.10.029
PMCID: PMC3646641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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