Defective peripheral B cell selection in common variable immune deficiency patients with autoimmune manifestations

Abstract excerpt

Common variable immune deficiency (CVID) is a heterogeneous disorder characterized by recurrent infections, low levels of serum immunoglobulins, and impaired vaccine responses. Autoimmune manifestations are common, but B cell central and peripheral selection mechanisms in CVID are incompletely understood. Here, we find that receptor editing, a measure of central tolerance, is increased in transitional B cells...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood groups and transfusion
• Share to Immunodeficiency and Autoimmune Disorders
• Share to T-cell and B-cell Immunology