Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescence

27 Sept 2022

Abstract excerpt

Cell senescence is a state of limited cell proliferation during a stress response or as part of a programmed process. When a senescent cell stops dividing, maintaining metabolic activity contributes to cellular homeostasis maintenance. In this process, the cell cycle is arrested at the G0/G1 phase. p16INK4A protein is a key regulator of this process via its cyclin‑dependent kinase inhibitor (CDKI) function. CDKI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Sirtuins and Resveratrol in Medicine
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36169180
DOI: 10.3892/mmr.2022.12861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescencePMID 36169180Read ↗

Sirtuins and SIRT6 in Carcinogenesis and in DietSemantic proximity Read ↗

Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clockSemantic proximity Read ↗

hnRNP A1 antagonizes cellular senescence and senescence‐associated secretory phenotype via regulation of SIRT1 mRNA stabilitySemantic proximity Read ↗

SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCCSemantic proximity Read ↗

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid FibroblastsSemantic proximity Read ↗

Tumor suppressor p16 <sup>INK4A</sup> is necessary for survival of cervical carcinoma cell linesSemantic proximity Read ↗

The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral GenomesSemantic proximity Read ↗

p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic MechanismsSemantic proximity Read ↗

SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.Semantic proximity Read ↗

Histone H4 lysine 16 acetylation regulates cellular lifespan.Semantic proximity Read ↗

Histone Modifications in Senescence-Associated Resistance to Apoptosis by Oxidative StressSemantic proximity Read ↗

Cellular senescence mediated by p16INK4A-coupled miRNA pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.