Article

CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 and E7 induces senescence in cervical cancer cells

2020-04-16

Abstract excerpt

<h4>ABSTRACT</h4> Human papillomaviruses (HPVs) such as HPV16 and HPV18 can cause cancers of the cervix, vagina, vulva, penis, anus and oropharynx. Continuous expression of the HPV viral oncoproteins E6 and E7 are essential for transformation and maintenance of cancer cells. Therefore, therapeutic targeting of E6 and E7 genes can potentially be used to treat HPV-related cancers. Previous CRISPR/Cas9 studies on in...

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Literature Corpus work: 5931a164-0924-5244-8d78-41803ab3db79
DOI: 10.1101/2020.04.16.044446

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