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Article

Simultaneous purifying selection on the ancestral MC1R allele and positive selection on the melanoma-risk allele V60L in south Europeans.

Molecular biology and evolution - 1 Dec 2013

Martínez-Cadenas Conrado, López Saioa, Ribas Gloria, Flores Carlos, García Oscar, Sevilla Arrate, Smith-Zubiaga Isabel, Ibarrola-Villaba Maider, Pino-Yanes Maria del Mar, Gardeazabal Jesús, Boyano Dolores, García de Galdeano Alicia, Izagirre Neskuts, de la Rúa Concepción, Alonso Santos

Abstract excerpt

In humans, the geographical apportionment of the coding diversity of the pigmentary locus melanocortin-1 receptor (MC1R) is, unusually, higher in Eurasians than in Africans. This atypical observation has been interpreted as the result of purifying selection due to functional constraint on MC1R in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24045876
DOI: 10.1093/molbev/mst158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24045876-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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