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Article

Neanderthal origin of the haplotypes carrying the functional variant Val92Met in the MC1R in modern humans.

Molecular biology and evolution - 1 Aug 2014

Ding Qiliang, Hu Ya, Xu Shuhua, Wang Chuan-Chao, Li Hui, Zhang Ruyue, Yan Shi, Wang Jiucun, Jin Li

Abstract excerpt

Skin color is one of the most visible and important phenotypes of modern humans. Melanocyte-stimulating hormone and its receptor played an important role in regulating skin color. In this article, we present evidence of Neanderthal introgression encompassing the melanocyte-stimulating hormone receptor gene MC1R. The haplotypes from Neanderthal introgression diverged with the Altai Neanderthal 103.3 ka, which...

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PMID: 24916031
DOI: 10.1093/molbev/msu180

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