MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project.

doi:10.1002/ijc.29018

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Article

MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project.

International journal of cancer - 1 Feb 2015

Pasquali Elena, García-Borrón José C, Fargnoli Maria Concetta, Gandini Sara, Maisonneuve Patrick, Bagnardi Vincenzo, Specchia Claudia, Liu Fan, Kayser Manfred, Nijsten Tamar, Nagore Eduardo, Kumar Rajiv, Hansson Johan, Kanetsky Peter A, Ghiorzo Paola, Debniak Tadeusz, Branicki Wojciech, Gruis Nelleke A, Han Jiali, Dwyer Terry, Blizzard Leigh, Landi Maria Teresa, Palmieri Giuseppe, Ribas Gloria, Stratigos Alexander, Council M Laurin, Autier Philippe, Little Julian, Newton-Bishop Julia, Sera Francesco, Raimondi Sara

Abstract excerpt

The MC1R gene is a key regulator of skin pigmentation. We aimed to evaluate the association between MC1R variants and the risk of sporadic cutaneous melanoma (CM) within the M-SKIP project, an international pooled-analysis on MC1R, skin cancer and phenotypic characteristics. Data included 5,160 cases and 12,119 controls from 17 studies. We calculated a summary odds ratio (SOR) for the association of each of the...

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PMID: 24917043
DOI: 10.1002/ijc.29018
PMCID: PMC4378685

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