Article
The interplay between natural selection and susceptibility to melanoma on allele 374F of SLC45A2 gene in a South European population.
PloS one - 1 Jan 2014
López Saioa, García Oscar, Yurrebaso Iñaki, Flores Carlos, Acosta-Herrera Marialbert, Chen Hua, Gardeazabal Jesús, Careaga Jesús María, Boyano María Dolores, Sánchez Ana, Ratón-Nieto Juan Antonio, Sevilla Arrate, Smith-Zubiaga Isabel, de Galdeano Alicia García, Martinez-Cadenas Conrado, Izagirre Neskuts, de la Rúa Concepción, Alonso Santos
Abstract excerpt
We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population (Basques from the North of Spain) and by resequencing the whole coding region and intron 5 of the 34 most and the 34 least pigmented individuals according to the reflectance distribution, we observed...
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