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Article

Ionizable networks mediate pH-dependent allostery in the SH2 domain-containing signaling proteins SHP2 and SRC.

Science signaling - 11 Nov 2025

Van Dyck Papa Kobina, Piszkin Luke, Gorski Elijah A, Nascimento Eduarda Tartarella, Abebe Joshua A, Hoffmann Logan M, Peng Jeffrey W, White Katharine A

Abstract excerpt

Intracellular pH dynamics regulate many cell biological processes. We developed a computational pipeline to identify pH-sensitive proteins and the molecular mechanisms that regulate their pH-dependent activity. By applying the pipeline to the phosphatase SHP2, which regulates signaling pathways that control pH-dependent cellular processes, we found that SHP2 phosphatase activity was sensitive to pH in vitro and...

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Share to Allosteric Regulation
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CSK Tyrosine-Protein Kinase

Share to Glutamic Acid

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Source

Identifiers

PMID: 41218103
DOI: 10.1126/scisignal.adt3018

Genes

SRC
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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