Article

Intracellular pH dynamics respond to extracellular matrix stiffening and mediate vasculogenic mimicry through β-catenin

2024-06-05

Abstract excerpt

Dysregulated intracellular pH (pHi) dynamics and an altered tumor microenvironment have emerged as drivers of cancer cell phenotypes. However, the molecular integration between the physical properties of the microenvironment and dynamic intracellular signaling responses remains unclear. Here, we identify a mechanistic link between ECM stiffness and pHi dynamics in driving vasculogenic mimicry (VM), an aggressive c...

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Literature Corpus work: 8a92fcaa-6025-5c9a-b0d9-0ab5bc1afbc9
DOI: 10.1101/2024.06.04.597454

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